德思特生物专注于中药(植物药)物质基础研究以及天然化合物、中药化学对照品实物生产供应

天然药物活性单体及中药标准品专业生产供应商

联系方式

028-85003950

联系方式

服务热线:

028-8500-3950

公司传真: 028-85589956
公司邮箱: 3001093092@qq.com
公司网址: www.028desite.com
公司地址: 四川省成都市温江区海科路西段128号5栋

发表文献展示

当前位置:首页 > 关于德思特 > 发表文献展示

Chlorogenic acid ameliorates mice clinical endometritis by activating Keap1/Nrf

时间:2021-04-07   浏览次数:  分享到:


期刊号:Journal of pharmacy and pharmacology
网站: https://doi.org/10.1093/jpp/rgab020t
日期:18 March 2021
Abstract:
Objectives Clinical endometritis is a common reproductive disorder in mammals that seriously
endangers animal health and causes economic losses worldwide. This study aims to use lipopoly
saccharide and Trueperella pyogenes exotoxin as modelling reagents (LC) to perfuse the mouse
uterus in order to establish a model of clinical endometritis and to investigate the anti-inflamma
tory and antioxidant effects of chlorogenic acid (CGA).
Methods In this study, five LC uterine perfusions were selected to model clinical endomet
ritis. The anti-inflammatory and antioxidant effects of CGA were clarified. Through HE staining,
proinflammatory cytokines, blood testing, NFκB and Keap1/Nrf2 signalling pathways and other
index changes to explore the protection mechanism of CGA.
Key findings After CGA treatment, the appearance, inflammatory damage and blood indicators of
the mouse uterus returned to normal. Simultaneously, CGA could inhibit the activation of NFκB
and reduce the release of inflammatory cytokines; CGA could also activate Keap1/Nrf2, promote
the dissociation of Keap1 and Nrf2 and significantly increase the expression of the downstream
genes HO-1 and NQO1.
Conclusions The above results together explain that five LC uterine perfusions can be used to es
tablish a mouse model of clinical endometritis. CGA can treat clinical endometritis by activating
Keap1/Nrf2 and inhibiting the NFκB signalling pathway
CGA (purity >98.0%) was purchased from Desite Bio (Chengdu, 
China).

热门新闻

Afrormosine CAS:550-79-8 中药对照品标准品

产品编码:DA0040产品名称:Afrormosine英文名:AfrormosineCAS登录...

查看更多

德思特
版权所有:成都德思特生物技术有限公司 Copyright © 2016   蜀ICP备16023840号-2
公司地址:四川省成都市温江区海科路西段128号5栋
公司电话:028-85003950

扫一扫关注德思特